The company has produced over fifty models since its inception. One of its most famous machines has been the Le Mans. This model was a further development of the 1971 750 V7 Sport designed by Guzzi engineer Lino Tonti. The V7 Sport was planned as the first five speed, 200 kg, 200 km/h, production motorcycle. With its disc brakes and additional displacement, the 850 Le Mans lived up to the promise of the V7 Sport. When the Le Mans debuted in 1976 it was among the 5 best performing road bikes available.

Six versions of the Le Mans have been produced, designated I, II, III, IV, V and V11 Le Mans. The I, II and III are 850 cc, the IV and V are 1000 cc and the V11 Le Mans is 1064 cc. The first two models had rounded air-cooling fins on the barrels while the latter have squared fins(known as "round-fin" and "square-fin"). All models have shaft drive. Early models use 36 or 40 mm Dellorto carburetors but the late model V11 Le Mans are fuel injected. All the machines in this series are highly regarded for their styling and performance.

In the '80s and '90s the California models were the biggest sellers. The first model appeared in 1972, and was based on a model sold to the L.A. police department. The combination of European performance and maneuverability coupled with laid back American styling has secured this model its cult following all over the world.

Most important production models

* Normale (498,4 cc) 1921 - 1924
* Sport 15 (498,4 cc) 1923 - 1928
* GT "Norge" (498,4 cc) 1928 - 1930
* Sport 14 (498,4 cc) 1929 - 1930
* Sport 15 (498,4 cc) 1931 - 1939
* GT 17 500 cc (499 cc) 1932 - 1939
* GTS (498,4 cc) 1934 - 1940
* Alce (498,4 cc) 1939 - 1945
* Airone (246 cc) 1939 - 1957
* Dondolino 500 cc (499 cc) 1946 - 1951
* Motoleggera 65 cc (64 cc) 1946 - 1954
* Astore (498,4 cc) 1949 - 1953
* Falcone (498,4 cc) 1950 - 1967
* Galletto 160 cc (159,5 cc) 1950 - 1966
* Cardellino 73 cc (73 cc) 1956 - 1965
* Zigolo (98 cc) 1953 - 1966
* Lodola Sport (175 cc) 1956 - 1966
* Stornello 125 cc (123,1 cc) 1960 - 1975
* Dingo 3 marce (48,89 cc) 1963 - 1976
* Dingo 4 marce (48,89 cc) 1963 - 1976
* Trotter Special M (48,89 cc) 1966 - 1973
* V7 700 cc (703,72 cc) 1967 - 1977
* V7 Special 750 (757,49 cc) 1968 - 1974
* Ambassador 750 (757,49 cc) 1969 - 1972
* Eldorado 850 (844,05 cc) 1972 - 1975
* V7 750 Sport (748,39 cc) 1971 - 1973
* 750 S (748 cc) 1974
* 750 S3 (748 cc) 1975- 1976
* Nuovo Falcone 500 (499 cc) 1971 - 1976
* V850 Le Mans (844,05 cc) 1975 - 1980
* 1000 SP (948,8 cc) 1977 - 1985
* V50 (490,29) 1977 - 1979
* V35 (346,2 cc) 1977 - 1980
* V1000 Idroconvert (948,8 cc) 1975 - 1980
* V50 Monza (490,29 cc) 1980 - 1985
* Le Mans III (844 cc) 1980 - 1985
* California II (948,8 c) 1981 - 1987
* V65 (643,4 cc) 1982 - 1987
* V35 Custom (346,2 cc) 1982 - 1987
* 850 T5 (844,05 cc) 1983 - 1987
* V65 Lario (643,4 cc) 1984 - 1989
* Le Mans 1000 (948,8 cc) 1984 - 1988
* California III (948,8 cc) 1987 - 1993
* 1000 GT (949 cc) 1987 - 1993
* Nevada 350 (346,2 cc) 1991 - 2001
* Daytona 1000 IE (992 c) 1991 - 1999
* Sport 1100 (1064 cc) 1994 - 1997
* V10 Centauro (992 cc) 1998 - 2001
* Quota 1100 ES (1064) 1998 - 2001
* V11 Sport (1064 cc) 1998 - 2001

* Nevada Classic 750 i.e. (744 cc)
* Stone - Stone Touring (1064 cc)
* California - California EV - California EV Touring (1064 cc)
* California Vintage (1064 cc) 2005 -
* V11 - V11 Le Mans (1064 cc) 1998 -
* Breva V750 i.e. (744 cc) 2002 -
* Breva 850 (877 cc) 2006 -
* Breva V1100 (1064 cc) 2005 -
* 1200 Sport (1151 cc) 2006 -
* Griso 850 (877 cc) 2006 -
* Griso 1100 (1064 cc) 2005 -
* Norge 1200 (1134 cc) 2005 -

Racing models

(not complete)

* C 4V (500 cc) 1924 - 1927
* 250 cc SS 1928 - 1933
* 250 cc Compressore 1938
* Albatros (250 cc ) 1928 - 1933
* Bicilindrica (500 cc) 1933 - 1951

* Dondolino (500 cc) 1946 - 1951
* Gambalunga (500 cc) 1946 - 1951
* Gambalunghino (250 cc) 1949 - 1952
* Quattro Cilindri (500 cc) 1952 - 1954
* Bialbero (250 cc) 1953 - 1955
* Bialbero (350 cc) 1954 - 1957
* Otto Cilindri (500 cc) 1955 - 1957

At the end of 1957 Moto Guzzi, Gilera and Mondial ceased participation in competitions.

* MGS-01 Corsa (1225 cc) 2004 -